Florence  is a city in and the county seat of Florence County, South Carolina, United States. It is at the intersection of Interstate 95 and Interstate 20 and is the eastern terminus of the latter. It is the county seat of Florence County and the primary city within the Florence metropolitan area. The area forms the core of the historical "Pee Dee" region of South Carolina, which includes the eight counties of northeastern South Carolina, along with sections of southeastern North Carolina. As of the 2010 census, the population of Florence was 37,056, and the estimated population in 2019 was 38,531.Florence is one of the major cities in South Carolina. In 1965, Florence was named an All-American City, presented by the National Civic League. The city was founded as a railroad hub and became the junction of three major railroad systems, including the Wilmington and Manchester, the Northeastern, and the Cheraw and Darlington.

 The city was once home to a major steel mill, the Florence Steel Corporation. The main campus of Coastal Carolina University is in Florence.

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