Seymour is a city in Jackson County, Indiana, United States. Its population was 17,503 at the 2010 census.
The city is noted for its location at the intersection of two major north/south and east/west railroads, which cross each other in the downtown area. The north/south line (the Jeffersonville, Madison and Indianapolis Railroad) was built in the 1840s and connected Indianapolis to the Ohio River at Jeffersonville. In 1852, Capt. Meedy Shields persuaded John Seymour into building the east/west railroad (the Ohio and Mississippi Railroad) through his land, and in return named the city in Seymour's honor.
The companies Aisin USA and Rose Acre Farms are headquartered in Seymour, and Cummins operates a plant in the area. The city is also home to the second largest high school gymnasium in the United States.


Seymour is located at (38.788581, -85.569091).
According to the 2010 census, Seymour has a total area of , of which (or 99.77%) is land and (or 0.23%) is water. The White River flows through the city from east to west in a channelized open cut known as "The Cut".

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